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                        1. betting 365 Medical Care, the world’s leading provider of products and services for people with chronic kidney failure, announced today that the company’s Frenova division has enrolled the first participants in its new initiative to develop the largest renal-focused genomic registry in the world.
                              
                          Along with this key milestone, the company also announced that Ali Gharavi, MD, Chief of the Division of Nephrology at Columbia University Irving Medical Center and Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons, will lead the project and provide scientific guidance as Principal Investigator.

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                          As a contract clinical development services company dedicated exclusively to medicines and medical products in renal research, Frenova orchestrates studies within the clinical footprint of betting 365 Medical Care, which provides dialysis treatments to about 350,000 patients around the globe. The renal-focused genomic registry represents a new business line within Frenova, which is based in betting 365 Medical Care’s Global Medical Office.

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                            As part of its growth strategy 2025, betting 365 Medical Care is using digital technologies and the capability to analyze huge amounts of data to develop new forms of renal therapy.

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                            • Nephrology has been under-represented in clinical research, even as rapid progress in gene sequencing and analysis has led to advances in precision medicine and individualized care in oncology, cardiology and other medical areas. Frenova’s new genomic registry will contain genetic sequencing data from chronic kidney disease patients worldwide, which will be used by researchers to improve the understanding of kidney disease. Frenova developed the registry after researchers identified the lack of a large-scale, renal-focused registry of genomic and clinical data as a major impediment to kidney disease research.

                            • “The new Frenova registry will close this gap by generating data that adds a clinical and genetic backbone to help support and fuel scientific innovation,” said Franklin W. Maddux, MD, Global Chief Medical Officer of betting 365 Medical Care. “The evidence for genetic drivers in kidney diseases is substantial, but much larger data sets will be needed to untangle the complex interactions that lead to kidney injury. By combining clinical and genetic sequencing data from ethnically and pathologically diverse participants, this genomic and phenotypic research resource will help scientists better understand how genetic variations in patients can lead to more precise diagnoses and therapies that help improve outcomes by individualizing care.”

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                                  “Our renal-focused genomic registry will be a sustainable and comprehensive tool for kidney-focused research,” said Kurt Mussina, President of Frenova. “It will bring patients, their families, patient advocacy groups, physicians and researchers together in the common cause of improving the lives of people living with kidney disease.”

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                                    Learn more about Frenova Renal Research at www.frenova.com

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                                        Diese Mitteilung enthält zukunftsbezogene Aussagen, die verschiedenen Risiken und Unsicherheiten unterliegen. Die zukünftigen Ergebnisse können erheblich von den zurzeit erwarteten Ergebnissen abweichen, und zwar aufgrund verschiedener Risikofaktoren und Ungewissheiten wie z.B. Veränderungen der Geschäfts-, Wirtschafts- und Wettbewerbssituation, Gesetzesänderungen, behördlichen Genehmigungen, Auswirkungen der Covid-19-Pandemie, Ergebnissen klinischer Studien, Wechselkursschwankungen, Ungewissheiten bezüglich Rechtsstreitigkeiten oder Untersuchungsverfahren und die Verfügbarkeit finanzieller Mittel. Diese und weitere Risiken und Unsicherheiten sind im Detail in den Berichten der betting 365 Medical Care AG & Co. KGaA beschrieben, die bei der U.S.-amerikanischen Börsenaufsicht (U.S. Securities and Exchange Commission) eingereicht werden. betting 365 Medical Care übernimmt keinerlei Verantwortung, die in dieser Mitteilung enthaltenen zukunftsbezogenen Aussagen zu aktualisieren.

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